One Pot Synthesis and docking study of some tetrahydrobenzo[b]pyran derivatives as extended spectrum class lactamase inhibitors for urinary tract infection

Abstract

A series of tetrahydrobenzo[b] pyran derivatives were synthesized and screened for the antimicrobial activity against Proteus vulgaris. Structures of newly synthesized compounds were confirmed by physicochemical, spectral and elemental analysis. The docking and Pharmacophore identification were carried out using Vlife MDS 4.3. The docking analysis showed that the all the inhibitors are showing the activity by blocking extended spectrum class lactamase. The pharmacophore identification showed the presence of Negative ionizable, Hydrogen bond donor, hydrogen bond acceptor and Aliphatic are important features required for extended spectrum class lactamase inhibition.