The effect of rice bran wax on physicochemical properties of curcuminoid-loaded solid lipid nanoparticles

Abstract

Keywords: Curcuminoid, High pressure homogenization, Rice bran wax, Solid lipid nanoparticles

Objectives: The aim of this study was to explore the potential of using rice bran wax as a natural lipid composition for curcuminoid-loaded solid lipid nanoparticles.

Methods: Blank solid lipid nanoparticle (SLN) formulations of three lipid types and concentrations; rice bran wax (RB), glyceryl behenate (GB) and cetyl palmitate (CP) at 2.5, 5 and 7.5%w/w were studied. SLN were prepared by a high pressure homogenization technique and characterized on their particle size, polydispersity index and zeta potential. SLN physical stability was also observed during storage. Curcuminoid-loaded SLN (C-SLN) were prepared and determined their physical characteristics and percentage of drug entrapment.

Results: The results showed that particle size of all SLN formulations ranged in nanosize with narrow size distribution and low zeta potential which indicating a good physical stability. SLN with RB had smaller size compared to GB and CP. The mean particle size of RB-SLN was slightly increased when a lipid concentration was increased from 2.5 to 7.5%w/w. Entrapment efficiency of the loaded-SLN with RB showed higher of loading amount than the loaded-SLN with GB or CP.

Conclusion: Curcuminoid-loaded solid lipid nanoparticles using rice bran wax was successfully prepared. This rice bran lipid carrier had better physical properties and entrapment efficiency. Therefore, the rice bran wax has a pharmaceutical potential usage as a natural lipid composition for SLN delivery systems.