Synthesis and characterization of sodium alginate conjugate: Preparation and evaluation of transdermal patches of losartan potassium using sodium alginate conjugate

Satheesha Babu BK, Srinivasa Rao K

Abstract


An emergence increasing evidence of antibiotic resistance in microorganisms has resulted in reduced
effectiveness of available conventional antimicrobial drugs and becomes a major concern for public health
worldwide. Antimicrobial peptides (AMPs) are regarded as excellent candidates of promising alternative
antibiotics owing to their higher or equal potencies and broad spectrum antimicrobial activities with less possibility
of resistance induction when compared to conventional antibiotic drugs.Among AMPs, short native α-helical
cationic antimicrobial peptides have been illustrated as potential antibiotic candidates because they contain small
and simple structure providing the advantages for chemical modifications and structure-activity relationship studies.
Interestingly, the small and simple structures are attractive and demonstrate as commercially feasible candidates for
further development in therapeutic or industrial uses. Therefore, this review focused on current discovered short native -
helical cationic antimicrobial peptides (10 amino acid residues in length) which are anoplin, temporin-H, and temporin-SHf.
This review also summarized these peptides in aspect of physico-chemical properties, activities and toxicities.


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