Anthelmintic activity of Manosa alliacea against Pheretima posthuma: Invitro and Insilico approach

Abstract

Manosa alliacea has been utilized to remedy many afflictions of humans. Literary works illustrate that it possesses numerous biological activities. Our analysis work aims to distinguish phyto-derived anthelmintic substances from M. alliacea against the enzyme β-tubulin and to consider the cause of its function in the molecular basis. In the present study, the isolated compounds from M. alliacea retrieved from the PubMed database, are subjected to docking analysis. Docking experiments have been conducted using Autodock Vina and PyRx tools. Subsequently, DruLiTo software was used to study drug-like predictions. Our study shows that the four phytochemicals of M. alliacea are very likely against the β-tubulin. Utilizing contemporary strategies, these phyto-compounds from a natural origin might establish a reliable medication or support lead identification. Identified hit compounds could be further taken for in vitro studies to examine their effectiveness versus helminths.