Anaphylactic Shock caused by a Selective Allergy to Ceftriaxone: A Case Report

Wichai - Santimaleeworagun

Abstract


Ceftriaxone has been wildly used due to once daily dosing. However, case with anaphylaxis secondary to ceftriaxone has been documented and the other β-lactam might be caution. We reported an 89 year-old patient who had history of type I hypersensitivity to ceftriaxone. This case could be use imipenem following by piperacillin/tazobactam for a few days with a good clinical outcome prior to antibiotic de-escalation. After switching to ceftriaxone, she developed anaphylaxis shock and the appropriate resuscitation was performed immediately. She had received ampicillin, cloxacillin, piperacillin/tazobactam and imipenem without any serious events. With our case report, the other β-lactam might be therapeutic choices in case of selective allergy to one of them but it can be hard to know except, they have experienced such medications. Moreover, the rechallenge β-lactam in type I hypersensitivity does not routinely reintroduce. The other classes of antimicrobial agents, not β-lactam, are the preferred options.

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References


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