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Integration of Thai traditional medicine into physicians' practice part 1: Conditions facilitating the integration

Katekaew Jehso, Sanguan Lerkiatbundit, Wantanee Wiroonpanich

Abstract


Chuanxiong Rhizoma (CR) is the dried rhizome of Ligusticum chuanxiong Hort. It is known as Kot-Hua-Bua in Thai traditional medicine. Two types of CR, raw CR and wine stir-fried CR, were commercially available in traditional drugstores in Thailand. Raw CR was found to have more inhibitory effect on ADP-induced platelet aggregation than wine  stir-fried  CR  (34.36 ± 5.80 vs. 9.31 ± 3.14%,  respectively; p = 0.009). Their chemical profiles using HPLC-DAD and TLC-UV-densitometric methods were similar, but the amount of several bioactive compounds found in wine stir-fried CR, e.g., senkyunolide H, senkyunolide I, ferulic acid, 3-butylidenephthalide, and levistolide A, were lesser. 5-Hydroxymethylfurfural was the artifact compound detected only in wine stir-fried CR. These results indicated that even both raw CR and wine stir-fried CR were the rhizome of the same herb, but their bioactivity and chemical quality were clearly different and should be concerned.

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References


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