Antihypercholesterol activity of costus speciosus water extract

Hari Susanti, Subagus Wahyuono, Ratna Asmah Susidarti, Ika Puspita Sari

Abstract


Abstract

Hypercholesterol is one of cause of cardiovascular disease. Costus speciosus is known empirically as an antihypercholesterol remedy. The study was conducted to determine the effect of water extract of Costus speciosus (CS) on cholesterol blood serum level of rat induced-propylthiouracil (PTU).

The antihypercholesterol activity performed on male Wistar rat induced 0.01% PTU (mixed in drinking water, 14 day-induction) was followed by administration of CS for 14 days. The animals were randomly divided into 7 groups : solvent  control (CMC Na 0.5%), positive control (simvastatin at dose 7.2 mg/kgBW) , negative control (water), CS at dose 50 mg/kgBW, 100 mg/kgBW, 200 mg/kgBW and normal control. The cholesterol levels were measured at day 0, 14th and 28th

The result showed that administration of CS at dose 200mg/kgBW is able to reduce the total serum cholesterol equal with simvastatin.

 

Keywords : Costus speciosus, water extract, PTU, total cholesterol level


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