ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF QUERCETIN WITH SOLID DISPERSION SYSTEM FORMATION USING HPMC MATRIX

Abstract

Purpose : The aim of the present study was to obtain raw quercetin materials using solid dispersion system with better solubility and dissolution rate than pure quercetin. Methods: The solid dispersion of Quercetin-HPMC was prepared by solvent method. Subsequently, the solid dispersion was tested for its solubility and in vitro dissolution. The physicochemical properties were characterized by powder X-ray diffractometer (PXRD), Differential Thermal Analyzer (DTA), FT-Infrared Spectrophotometer and Scanning Electron Microscope (SEM). Results :  Solubility test, dissolution test and physicochemical property characterization on the solid dispersion of Quercetin-HPMC then were compared to those on the pure quercetin and the physical mixture. Based on the results of one-way ANOVA test using IBM SPSS statistic ver 23, P > 0.05 indicated a significant difference in the solubility and dissolution rate. Conclusions: Quercetin - HPMC 3 Cps solid dispersion (SD) was formed in the forms of amorphous substance which resulting in the increase of solubility and dissolution rate. These findings may enhance bioavailability in order to increase drug efficacy.