Formulation, characterization, and in vitro–in vivo evaluation of self microemulsifying drug delivery system of Ebastine by spray drying technology using solid carriers
Abstract
Aim of study was to develop and optimize novel liquid SMEDDS and solid form by spray drying method using solid carrier of an anti-allergic drug, Ebastine, a BCS class II drug. Preliminary screening was carried out with Rice Bran Oil, Tween 40, Capryol 90. Solid state characterization was performed. Drug-Excipient compatibility studies were performed. The droplets of optimized SMEDDS formulation were found to be spherical in size of 100-260 nm and emulsification efficiency of 83.72 ± 0.27% drug release at the end of 40 minutes with a significant increase in dissolution rate compared to the marketed drug suspension. The optimized SMEDDS formulation charged for the accelerated stability studies at 40 0C/75% RH for three months revealed to be stable.
Group of mice were sensitized intraperitoneal injections of ovalbumin. mice were observed in OVA-sensitized and -challenged mice. Nasal symptoms will be evaluated 2 minutes later by counting the time of nasal rubbing and number of sneezing events for 10 minutes. This procedure will be carried out for 10 days starting from Day 21. Results indicate that ebastine prevents airway inflammation.
In conclusion, the solid SMEDDS is a promising solid dosage form for poorly water soluble and low bioavailability drugs.
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