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Comparison of sedimentation stability of ampicillin trihydrate suspensions using near infrared extinction profiles

Padala Narasimha Murthy, Meduri Vimala Devi, Sudhir Kumar Sahoo, Anjan Kumar Mahapatra, Madhusmruti Khandai

Abstract


Suspensions are one of the most important and popular dosage forms.  A large number of drugs are formulated in the form of suspensions and are available commercially.  Stability studies of suspensions are very important to enable the patient to receive the intended amount of the medicine(s) in the dose administered. Physical stability of ampicillin suspensions was studied in terms of sedimentation stability in a rapid way employing infrared extinction profiles by using the instrument Separation analyzer (LUMiReader®) in the present work. The LUMiReader® instantaneously measures the extinction profiles of the transmitted light across the entire length of a suspension sample employing STEP-Technology (Space- and Time-resolved Extinction Profiles Technology). Ampicillin trihydrate suspensions were formulated with different suspending agents like methylcellulose (MC), hydroxypropyl methylcellulose (HPMC), sodium carboxymethylcellulose (SCMC) and mucilage of Plantago ovata (POM) and their infrared extinction profiles were compared to determine their sedimentation stability. Instability indices determined on different suspension formulations indicated that SCMC and POM are preferable suspending agents for the preparation of stable suspensions of ampicillin trihydrate.

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