ANTI-INFLAMMATORY ACTIVITY OF NEW 1,3,4-OXADIAZOLE DERIVATIVES:(TJPS-2020-0186.R2)

Abstract

 A new series of 1,3,4-oxadiazole derivatives(3a-j) were synthesized by reacting p-toluic benzhydrazide (1) and substituted aromatic aldehydes (2) in the presence of ceric ammonium nitrate (CAN) as catalyst and dichloromethane as a solvent medium. The structures of the new compounds were assigned based on IR, 1H-NMR, and Mass spectral data and further evaluated for their In-Vitro anti-inflammatory potential using various protein denaturation methods following bovine serum and egg albumin assay. Some tested compounds 3e, 3f, 3i displayed moderate anti-inflammatory activity compared to the standard diclofenac sodium.

;TJPS-2020-0186.R2