Behaviour of polymers and In-Vitro evaluation on Gastroretentive Nifedipine sustained release floating tablets:(TJPS-2021-0070)

Abstract

The effect of polymers and their combination on release pattern, initial burst release, and floating behaviour were studied. Out of four polymers, two polymers such as cellulose derivatives like highly viscous polymer, low viscous and their combinations, and other two polymers used were from natural sources and their combinations were studied. The percentage of drug release was compared with the theoretical model. Formulated gastro retentive Nifedipine floating tablets were evaluated with various parameters such as wetting time, floating behaviour, hardness test, swelling studies, and drug release. The combinations of natural polymers shown the best result on drug release and initial burst release like 98.28 and 22%, respectively with floating lag time of 90 sec. Dissolution data were fitted into various mathematical equations to understand the concept of drug release. Based on result it was found that optimized formulation follows the Hixon Crowell equation (r2 > 0.966) and zero-order drug release (r2 > 0.968). The conclusion is that gastroretentive Nifedipine floating tablets followed dissolution controlled mechanism of drug release. The similarity factor f2 and dissimilarity factor f1 were found to be 76.02 and 4.32, respectively for Nifedipine release from the optimized batch in comparison with the theoretical drug release profile.