NEUROPROTECTIVE AND NOOTROPIC EVALUATION OF MYRISTICA MALABARICA ON DIABETES INDUCED COGNITIVE IMPAIRMENT IN EXPERIMENTAL ANIMALS: PROMISING FOR CONTROLLING THE RISK OF ALZHEIMER’S DISEASE:(TJPS-2021-0011.R1)

Abstract

The intent of this study is to explore neuroprotective and memory enhancing properties of Myristica malabarica (MM) leaf extracts on diabetic induced cognitive decline rats. The models of Y maze and Morris water maze were selected for nootropic activity and neuroprotective properties were deliberate by assessing the levels of Ach, MDA, SOD, NO, CAT and GSH in diabetic rat brains. Significantly improved memory and learning with 100 mg/kg (p<0.01) and 200 mg/kg (p<0.001) of EAMM (L) and MAMM (L) in Y maze and Morris water maze models. Significant effect was observed in all the extracts with two doses when compared with diabetic control on day 75. 
The levels of AchE (p<0.001), MDA (p<0.01), NO (p<0.05) were decreased significantly and significantly raised (p<0.01) levels of SOD, CAT and GSH with MAMM (100 and 200 mg/kg) compared with disease control. Further studies on Myristica malabarica leaf are needed as evidence of cognitive impairment in defence against diabetes has been shown to expose its mode of action.