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Mucus secretion stimulation: a mechanism in gastroprotective effect of Zingiber officinale

Gaewbpragaan Chantharangsikul, Worawan Kitpati, Noppamas Soonthornchareonnon, Achariya Sailasuta, Arunporn Itharat, Wisuda Suvitayavat

Abstract


There are several studies on the gastroprotective effect of Z. officinale, however, the nature of this effect has not been fully elucidated. The present study investigated the gastroprotective activity and underlying mechanism of the 95% ethanolic extract of Zingiber officinale. The extract was evaluated against gastric ulceration induced either by hydrochloric acid (HCl), or water immersion restraint stress (WIR) or aspirin (ASP). Pretreatment with the extract (0.1, 0.25, 0.5 or 1.0 g/kg) for 30 minutes before inducing an ulcer by HCl, WIR and ASP decreased gastric lesions in a dose dependent manner with maximal inhibitions of 81.5, 44.2 and 68.1%, respectively. Further, the involvement of gastric secretion on this antigastric ulcer activity was determined in a model of histamine–induced secretion in gastric fistulae of rats. The extract significantly increased visible gastric mucus secretion and had a tendency to increase the secretory rate of soluble gastric mucus. Nevertheless, it had no effect on gastric pH, acid and pepsin secretion. These results demonstrate that the Z. officinale extract exerts moderate gastric ulcer protection by increasing gastric mucus secretion.

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