Antiproliferative effects of Pereskiopsis diguetii, Caralluma speciosa and Euphorbia ritchiei hydroalcoholic extract
Abstract
To date, cancers remain to be global health problem. The toxicity and the emergence of chemotherapy resistance of currently prescribed anticancer agents highlight the need for the discovery and the development of novel anticancer drugs. The previous successes in the discovery of anticancer agents and other biologically active compounds from diverse types of flora support the value of plants as natural resources for the screening of novel drugs. However, the pharmacological data of succulent plants are largely limited. Here, we screened hydroalcoholic extract of selected succulent plants for their anticancer activities. Pereskiopsis diguetii (F.A.C. Weber) Britton & Rose, a member of cactaceae family, exhibited a growth inhibitory effect against colorectal cancer cell line HT29, hepatocellular carcinoma cell line HepG2 and head and neck cancer cell line HN22. Caralluma speciosa (N.E.Br.) N.E.Br., a member of apocynaceae family, inhibited the proliferation of HT29 and HN22 cells. Euphorbia ritchiei (P. R. O. Bally) Bruyns. exhibited growth inhibitory effect against HepG2, HN22 and cervical cancer cell line HeLa.
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