Quick-Fat diet inhibits the development of diabetes in Spontaneously Diabetic Torii (SDT) rats

Takeshi Ohta, Takahisa Yamada, Taiichiro Kamiya, Takayuki Gotoh, Masataka Tsubaki, Masami Shinohara

Abstract


The diabetic animal model is very useful for developing functional foods and medicinal drugs. Spontaneously Diabetic Torii (SDT) rat, a non-obese type 2 diabetic model, is one of the hopeful models to play an important role for research and development of the diabetic therapy. The objective of this study was to investigate effects of Quick-Fat (QF) diet on the progression of diabetes in SDT rats. The SDT rats were divided into 2 groups at 5 weeks of age, which were fed a standard diet or QF diet for 34 weeks. Body weight, calorie intake, blood glucose, and ketone body levels were measured every 2 weeks. The cumulative incidence of diabetes or cataract was also determined. Blood electrolyte levels, such as sodium and potassium, were measured at 25 and 30 weeks of age. The SDT rats fed a QF (QF-SDT) showed an increase of body weight after 7 weeks of age and a decrease of calorie intake after 29 weeks of age. Blood glucose levels in the QF-SDT group decreased after 23 weeks of age, and blood ketone body levels in the QF-SDT group increased after 9 weeks of age. In addition, reduction in the incidence of diabetes or cataract was observed in the QF-SDT group. The changes in blood electrolyte levels were observed in the QF-SDT group at 25 weeks of age, but no changes were observed at 30 weeks of age. SDT rats fed a QF diet showed the delay of diabetic incidence, accompanied by an increase in blood ketone body levels.

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References


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