The protective effect of lycopene-rich products on skin photodamage: a systematic review and meta-analysis of randomized controlled trials

Witoo Dilokthornsakul, Teerapon Dhippayom, Piyameth Dilokthornsakul

Abstract


Background: Ultraviolet (UV) radiation has known as a major cause of photodamage, photoaging and skin cancer as it involves in reactive oxygen species generation. Several natural antioxidants including lycopene has been suggested for photoprotection. However, the protective effect of lycopene on skin photodamage is still controversial.

Objective: To evaluate the protective effect of lycopene-rich product on skin photodamage

Method:  A systematic literature search was conducted in PubMed, Scopus, CINAHL, and Cochrane Library from inceptions to March 2018. Randomized placebo controlled trials determining the effect of lycopene-rich products on photodamage in healthy volunteer were included. Studies adding other antioxidants except carotenoids were excluded. Risk of bias version 2.0 was used to assess the quality of included studies. Primary outcome was intensity of skin erythema formation. Meta-analysis was performed under random-effects model.

Results: A total of four studies were included in systematic review with a total of 99 participants. Only two studies were included in meta-analysis. Lycopene-rich products with the lycopene content of 8-20 mg/day significantly reduced skin erythema formation, with mean difference of -2.35 when compared to control (95% confidence interval; -3.65 to -1.05, I2 =0.0%). In molecular level, lycopene significantly inhibited UV radiation-induced expression of matrix metalloproteinase-1 (MMP-1), heme-oxygenase 1 (HO-1), and intercellular adhesion molecule 1 (ICAM-1) compared to olive or soybean oil (p <0.05).

Conclusion: Lycopene-rich products had a potential to be developed as a nutraceutical for photoprotection as it showed protective effects on skin photodamage.


Full Text:

176-182;PDF

References


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