Patrick Chukwuyenum Ichipi-Ifukor


Aims: This study examined the effects of palm oil and palm oil extracts pre-treatment on the activities of serum and tissue amino transferases in acute cadmium induced toxicity.

Methodology: Six experimental groups was used and group A served as the control while group B was administered 20mg/Kg-1 body weight of cadmium chloride orally, groups C-F were administered 5mlKg-1 body weight of crude palm oil (CPO), silica gel extract (SGE), bleached extract (BE) and unsaponifiable extracts (UPE) of palm oil respectively for 28 days before administration of 20mg/Kg-1 body weightof cadmium chloride orally on the 29th day. Animals were sacrificed on the 29th, 30th and 31st days within intervals of 12, 24 and 48 hours post cadmium administration for tissue and serum enzyme assay and liver histological analysis.

Results: There was significant increase (p<0.05) in the activities of ALT and AST in the tissues (liver, kidney, heart and muscle) and serum of group B relative to group A, while the brain showed no relative significant (P>0.05) changes in group B relative to group A after 12, 24 and 48 hours. Although the activities of these enzymes also increased in groups C and D relative to group A, it reduced significantly relative to those administered Cadmium only (group B). There was no significant alteration in the liver membrane integrity in all groups and the pattern for increase in the activities of the amino transferases was Liver>Kidney>Muscle>Heart>Serum>Brain after 12, 24 and 48hours.

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