Synthesis and evaluation of PI3Kγ enzyme inhibitory activity of Novel (1H-pyrazol-4-yl)methanamine

Abstract

A series of (1H-pyrazol-4-yl)methanamines have been synthesized and then were evaluated for the PI3Kγ enzyme inhibitory potential. Minor modification of the initially synthesized molecules offered significant improvement of the inhibitory potential from 36% to 73%. Some selected compounds were then subjected to the in silico study for understanding the most likely interactions to aid the future researches focusing on discovering novel inhibitors against the PI3Kγ enzyme