Statistical Design, Formulation and Evaluation of Gastro Retentive Floating Tablets for Moxifloxacin using Natural and Semisynthetic Polymers

Raghavendra Kumar Gunda, A Vijayalakshmi

Abstract


Purpose: The objective of current study is to develop gastro retentive formulation for Moxifloxacin using various drug release modifiers. Moxifloxacin, novel synthetic fluoro quinolone, antibacterial agent. Methods: Floating tablets of Moxifloxacin. HCl were prepared using variable amounts of HPMCK100M, Lannea coromandelica gum (LCG) with effervescent mixtures as per 32 factorial design by direct compression technique. Amount of release modifiers required to obtain the prolonged release of drug was chosen as independent variables, X1 and X2 respectively whereas, time taken for 10%, 50%, 75% , 90% of drug release were chosen as dependent variables. Results and Discussion: 9 formulations were developed and are checked for pharmacopoeial tests. Results shows that all the factorial batches were lie within the standard limits. Dissolution parameters of all formulations were subjected to kinetic fitting, various statistical parameters were determined. Polynomial equations were developed and verified for dependent variables. Conclusion: Formulation (F5) containing 50 mg of HPMCK100M and 50 mg of LCG, is the best formulation showing similarity f2=71.733, f1= 4.272 with the marketed product (AVELOX). Formulation F5 follows Higuchi’s kinetics, Non-Fickian Diffusion first order kinetics (n= 1.098).

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References


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