Hemogram results and renal function before and after administration of black cumin seed oil (BCSO) in healthy volunteers:(TJPS-2020-0301.R2)

Abstract

This study was aimed to determine the impact of the 20-day administration of BCSO on kidney function in healthy volunteers. Safety or tolerability tests were carried out using a pre and post control design in 36 healthy volunteers. The volunteers had to hold a valid health certificate from the hospital, be willing to be involved in the research as evidenced by their willingness to complete and sign an informed consent and be aged between 18 and 50 years. Pregnant women and participants allergic to BCSO were excluded. BCSO was given for 20 days in 3 dose regimes: 3 x 0.5 ml, 3 x 1 ml, and 3 x 1.5 ml. Blood pressure, pulse, weight, and blood chemistry of kidney function were observed and hemograms and urinalyses were performed before and after treatment. One-way ANOVA and a repeated measures analysis were used to examine the mean difference of clinical parameters outcomes. BCSO administration with the three-dose levels for 20 days did not change blood pressure, hemogram, blood urea levels, blood creatinine levels, or specific gravity and urine pH (p>0.05). The administration of BCSO is safe and can be tolerated by the kidneys and the hematopoietic system.