Group-Based Qsar on Benzothiazole Derivatives For Development of Potent Anti-Cancer Compounds:(TJPS-2019-0123.R1)

Abstract

To develop potent anticancer compounds using benzothiazole scaffolds GQSAR analysis was performed on 41 reported benzothiazole derivatives for identification of structural fragments. Benzothiazole dataset was fragmented in to two fragments (R1 and R2). GQSAR models were generated using MLR. GQSAR analysis revealed presence of hydrophobic groups on R1 will potentiate anticancer activity. The generated models are giving insight into the benzothiazole structural requirements which will be optimized for design of anticancer drugs.

:TJPS-2019-0123.R1