Polymer as Precipitation Inhibitor of Weak Base Drug: An Update and Brief Review:(TJPS-2020-0297.R1)

Abstract

Precipitation due to supersaturation phenomenon and intraluminal solubilization behavior is mainly faced on reducing bioavailability particularly for weak base drugs. Incomplete and extend of absorption can be avoided by modification of drug-excipient interaction e.g. polymers. This interaction is proposed to stabilize the amorphous form of drug through reducing nucleation followed by crystal growth. Therefore, polymers can be utilized to inhibit the precipitation phenomenon through their interaction with poorly water soluble and weak base drug. This review discussed the brief and recent updates on polymer as precipitation inhibitor of weak base drug during intraluminal solubilization behavior e.g. mechanism, factors, and polymer application.